(B) Surface representation of RBD ACE2-binding site with the overlapping epitopes targeted by major classes of neutralizing antibodies. The three ACE2-binding regions (top, base, and knob) and the overlapping epitopes (sites A, B, C, and D), classified by Wilson and co-workers (Yuan et al., 2021), are shown. Emergent mutations in the ACE2-binding site of circulating variants are shown in red ball and stick representation.
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